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Aevum Vita 313 | ISCA UK Ltd
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Aevum Vita 313
Multifunctional Additive / Natural Blend
INCI: Ethylhexyl glycerin, levulinic acid, phenyl propanol, pentylene glycol, perillic acid

Aevum Vita 313 is a naturally derived multifunctional cosmetic ingredient, ideal for use in ecolabel approved formulations. It’s a skin conditioning agent containing plant based analogs of widely used substances such ethylhexylglycerin and pentylene glycol, perillic acid: an ingredient with recognised anti-inflammatory and antioxidant properties.

This optimised combination of emollients allows the creation of modern, quickly absorbed, non-tacky formulations that exhibit excellent moisturisation and humectancy. Additionally, the inherent antimicrobial properties of the ingredients, allows formulators to create “self-preserving” cosmetics.

Moisturisation
Emolliency
Natural Origin
“Preservative Free“
ECOLABEL COMPLIANT
Recommended Dosage
IN USE CONCENTRATIONS ISCA RECOMMENDATION EU COSMETIC REGULATION (MAX)
LEAVE ON 0.7 - 1.5 % no limit
RINSE OFF 0.7 - 1.5 % no limit
In use concentrations vary according to the formulation type and the other ingredients present. The correct use dosage should be determined by microbial challenge testing of the finished formulation. ISCA UK offers discounted challenge testing to our customers.
Recommended Applications
SHAMPOO, SHOWER GEL (RINSE-OFF) Deodorants Oral Care
CREAM, LOTION
(LEAVE-ON)
Wet wipes   Eye Care
Hair care Lip Care CHILDREN UNDER 3
Use scenarios derived from evolution of cosmetic regulation guidelines and preservative performance for typical formulations.
Overview Documentation

Documents related to Aevum Vita 313 are available to download.

If you require other material or statements, please do not hesitate to contact us.

Formulations with Anti-Microbial Data

A range of example formulations using Aevum Vita 313 have been developed and microbiologically evaluated. Our formulations demonstrate high versatility and compatibility across many product types.

Example Prototype Formulation 1

Free Spirit Calming Body Mist

INGREDIENT %
Aqua 77.9
Polysorbate-20 10.0
Rosa Damascena Flower Water 8.0
Aevum Vita 313 2.0
Anthemis nobilis (Roman Chamomile) Floral Water 1.0
Citrus Aurantium Bergamia (Bergamot) Fruit Oil 0.5
Lavandula Angustifolia (Lavender) Oil 0.5
Geraniol 0.1
Citric Acid/Sodium Hydroxide to pH 3.28 q.s.
Passed an EP Challenge Test (Report No. 25158)
Formulation 1

Even in formulations with high essential oil content and water activity, Aevum Vita 313 at 2.0% is enough to provide the formulation with protection against microbial growth.

Example Prototype Formulation 2

Pro-Vitamin Balancing Serum

INGREDIENT %
Aqua 79.0
Rosa Damascena Flower Water 10.0
Niacinamide 5.0
Panthenol 3.0
Aevum Vita 525 1.5
Aevum Vita 313 1.0
Allantoin 0.5
Citric Acid/Sodium Hydroxide to pH 3.7 q.s.
Passed an EP Challenge Test (Report No. 25076)

Aevum Vita 313 provides humectancy and enhanced sensory benefits due to the blend of emollients.

Formulation 2

This formulation is self-preserving. This has been undoubtedly proven as the result of utilizing Aevum Vita 313 at 1.0%. Control studies omitting Aevum Vita 313, resulted in a failed EP challenge test.

Additionally, this serum has been assessed in a time-kill test (based on ASTM E2315 (2016)) against C. acnes for its suitability as an anti-acne product.

This formulation resulted in a 99.99% reduction in C. acnes within 30 seconds. This demonstrates suitability towards both rinse-off and leave-on products.

Time % Reduction
30 seconds 4 log reduction - 99.99
2 minutes 4 log reduction - 99.99
1 hour 4 log reduction - 99.99
4 hours 4 log reduction - 99.99
Test species: C. acnes Inoculation: 3.5 x105 cfu/g

Example Prototype Formulation 3

Nourishing Ceramide Hand Cream

INGREDIENT %
Aqua 66.1
Mangifera Indica Seed Butter 8.0
 Prunus Amygdalus Dulcis Oil 7.0
Glyceryl Stearate SE 5.0
Glycerin 3.0
Aevum Vita 525 3.0
Dimethyl Sulfone 3.0
Glucosamine 3.0
Aevum Vita 313 1.5
Tocopherol 0.2
Ceramide 0.2
Citric Acid/Sodium Hydroxide to pH 3.0 q.s.
Our formulation has passed an EP Challenge test (Report No. 25108)

Example Prototype Formulation 4

Anti-fungal Squalene Foot Cream

INGREDIENT %
Aqua 79.3
Mangifera Indica Seed Butter 8.0
Glyceryl Stearate SE 5.0
Aevum Vita 525 3.0
Glycerin 2.0
Glyceryl Oleate 1.0
Aevum Vita 313 1.0
Squalene 0.5
Tocopherol 0.2
Citric Acid to pH 3.0

q.s.

Our formulation has passed an EP Challenge test (Report No. 25126)
Formulation 4

This leave-on formulation was tested against T. rubrum, the fungus responsible for Athlete’s foot.

In a time-kill suspension test based on ASTM E2315 (2016) method, this squalane foot cream gives a 99% reduction of T. rubrum in 60 minutes.

Further work to achieve a 4-log reduction would be required, although at just 1% Aevum Vita 313, this shows potential for use in such applications.

Example Prototype Formulation 5

Anti-bacterial Mental Clarity Shower Gel

INGREDIENT %
Aqua 54.75
Sodium Lauryl Sulfate 20.00
Cocoamidopropyl Betaine (30%) 10.00
Lauryl Glucoside 7.00
Glycerin 5.25
Rubus Idaeus Seed Oil 1.00
Aevum Vita 313 1.00
Mental Clarity Essential Oil Blend* 0.50
Propylene Glycol 0.50
Citric Acid to pH 3.48 q.s.
*Citrus grandis (Grapefruit) peel oil, Citrus aurantium bergamia (Bergamot) fruit oil, Cupressus sempervirens (Cypress) leaf oil, Linalool, Limonene, Citral1 Our formulation has passed an EP Challenge test (Report No. 25127-A)
Formulation 5

Aevum Vita 313 provides a natural and gentle, yet effective, alternative to commercial active ingredients for anti-bacterial products.

In anti-microbial kill-tests, Aevum Vita 313 has proven powerful against cultures of mixed bacteria, giving anti-bacterial results comparable to commercial active ingredients, such as triclosan and o-phenylphenol.

Contact Time % Reduction
30 seconds 4 log reduction - 99.99
60 seconds 4 log reduction - 99.99
Test species: P. aeruginosa, S. aureus, E. coli, E. hirae Inoculation: 1.7 x106 cfu/g

Example Prototype Formulation 6

Arrowroot Deodorant Balm

INGREDIENT %
Arrowroot Powder 30.0
Mangifera Indica Seed Butter 20.0
Polysorbate-20 15.0
PEG-40 Castor Oil 10.0
Cetearyl Alcohol 8.0
Apricot Kernel Oil 7.0
Glyceryl Stearate S/E 5.0
Tapioca Starch 3.0
Aevum Vita 313 2.0
Anhydrous formulation – Challenge test not required.
TVC after 6 weeks showed no growth
Formulation 6

This formulation was tested in a time -kill suspension test against Staphylococcus hominis (S. hominis), a common bacteria associated with the production of odor in sweat.

Using Aevum Vita 313 at 2.0% gave a 4 - log reduction (99.99%) in S. hominis after 4 hours. The formulation demonstrates potential for Aevum Vita 313 not only provide microbial protection over time, but also to synergistically enhance the effectiveness of other active deodorising ingredients.

Contact Time % Reduction
5 minutes 85.38
4 hours 4 log reduction - 99.99
Test species: S. hominis Inoculation: 3.90 x106 cfu/g

Example Prototype Formulation 7

Chamomile and Witch Hazel Intimate Wash

INGREDIENT %
Aqua 67.23
Cocoamidopropyl Betaine (30%) 16.67
Sodium Lauryl Sulfate 7.00
Cocoglucoside 3.00
Hamamelis Virginiana Water 2.50
Lauryl Glucoside 1.00
Aevum Vita 313 1.00
Glycerin 0.50
Glyceryl Oleate 0.50
Anthemis Nobilis Flower Oil 0.50
Lactic Acid (88%) 0.1
Citric Acid to pH 3.56 q.s.
Our formulation has passed an EP Challenge test (Report No. 25135)
Formulation 7

Aevum Vita 313 provides a natural and gentle alternative to commercial active ingredients for feminine hygiene products.

In anti-microbial kill-tests, Aevum Vita 313 has demonstrated activity against Candida albicans.

Further formulation work could see an increase in percentage reductions at the lowest contact times.

Contact Time % Reduction
30 seconds 87%
120 seconds 89%
180 seconds >90%
Test species: C. albicans Inoculation: 1.10 x106 cfu/g

Example Prototype Formulation 8

Anti-Acne Beta-Carotene Face Wash

INGREDIENT %
Aqua 61.23
Cocoamidopropyl Betaine (30%) 16.67
Sodium Lauryl Sulfate 10.00
Decyl Glucoside 2.50
Niacinamide 2.00
Hamamelis Virginiana Water 2.00
Sodium Chloride 2.00
Aevum Vita 313 1.00
Lauryl Glucoside 1.00
Aloe Barbadensis Leaf Juice 0.60
Daucus Carota Sativa (Carrot) Seed Oil 0.50
Glycerin 0.50
Citric Acid to pH q.s.
Our formulation has passed an EP Challenge test (Report No. 25155)
Formulation 8

Aevum Vita 313 provides a natural and gentle, yet effective, alternative to commercial active ingredients for anti-acne products.

In anti-microbial kill-tests, Aevum Vita 313 has proven powerful against the bacteria C. acnes, achieving a 4-log reduction within 30 seconds contact time.

Contact Time % Reduction
30 seconds 99.99%
120 seconds 99.99%
180 seconds 99.99%
Test species: C. acnes Inoculation: 2.40 x106 cfu/g

Example Prototype Formulation 9

Revitalising Apple and Mint Shampoo

INGREDIENT %
Aqua 48.6
Sodium Lauryl Sulfate 20.0
Cocoamidopropyl Betaine (30%) 10.0
Lauryl Glucoside 8.0
Glycerin 6.0
Pyrus Malus (Apple) Fruit Extract 5.5
Aevum Vita 313 1.0
Propylene Glycol 0.5
Mentha Spicata (Spearmint) Oil 0.4

Citric Acid to pH 3.6

q.s.
Our formulation has passed an EP Challenge test (Report No. 25092)
Formulation 9

Aevum Vita 313 at 1% provides a natural and gentle alternative to commercial active ingredients for transparent anti-dandruff products.

In anti-microbial kill-tests, Aevum Vita 313 has proven powerful against the bacteria C. acnes, achieving a 4-log reduction within 30 seconds contact time.

Contact Time % Reduction
30 seconds 98%
120 seconds 99%
180 seconds >99%
Test species: M. furfur Inoculation: 4.70 x105 cfu/g

Example Prototype Formulation 10

Soothing Elderflower and Iris Toner

INGREDIENT %
Aqua 92.25
Niacinamide 5.0
Aevum Vita 313 2.0
Propylene Glycol 0.50
Elderflower and Iris Fragrance Oil 0.25
Citric Acid to pH 3.97 q.s.
Our formulation has passed an EP Challenge test (Report No. 25145)
Formulation 10

Aevum Vita 313 provides a gentle sensory properties and has shown to be compatible to commonly used preservative systems.

Feels hydrating on skin when applied

Good in-use and after-feel

Blind product testing compared a liquid toner containing Aevum Vita 313 against three other formulations, where only the preservative system differed.

Average rankings showed that all four formulations were comparable, demonstrating Aevum Vita 313’s high potential and compatibility to replace current preservative systems.

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